Synthesis, characterization, and antimicrobial activity of novel Schiff bases and their Ni (II) metal complexes


Satyanarayana Kandala
Department of Chemistry, Kakatiya University, Warangal, TS-506 009, India.

Ravinder Manchal
Department of Chemistry, Chaitanya Deemed to be University, Warangal, TS-506 001, India.


Chromone based Schiff bases and their Ni (II) metal complexes were synthesized from 3-formyl chromone and amino methylpyridines. Schiff base ligands and their metal complexes were characterized systematically by spectroscopic techniques (NMR, IR, UV, and HRMS), magnetic moment and elemental analysis. Spectroscopic and magnetic moment studies revealed that Ni(II) complexes have octahedral geometry. The complexes have screened for their in vitro antibacterial and anti-fungal activity compared with standard drugs streptomycin and fluconazole. [Ni (L3)2(H2O)2] complex has shown significant growth inhibitory activity against selected types of bacteria strains S. aureus and K. pneumonia than the ligands and [Ni(L2)2(H2O)2] complex has exhibited moderate anti-bacterial activity. Further, [Ni(L3)2(H2O)2] has shown excellent antifungal activity against A. Niger and A. Flavus.