Novel 3-Formylchromone Schiff bases containing Co (II) metal complexes: Synthesis, characterization and evaluation of biological activity

Authors

Satyanarayana Kandala
Department of Chemistry, Kakatiya University, Warangal, TS-506 009, India.

Ravinder Manchala
Department of Chemistry, Chaitanya Deemed to be University, Warangal, TS-506 001, India.

Abstract

A series of anti-bacterial and anti-fungal chromone schiff base scaffolds and their Co (II) metal complexes have been synthesized and characterized with spectroscopic techniques NMR, IR, UV–vis and HRMS magnetic moment and elemental analysis. Magnetic susceptibility measurements, IR and electronic spectral data suggest a six-coordinated octahedral geometry for these complexes. The magnetic moment values of all Co (II) complexes can be found between 3.92 – 3.98 BM. The complexes were screened for their anti-bacterial and anti-fungal activity study. The results were compared with standard drugs fluconazole and streptomycin. Complex [Ni (L3)2(H2O)2] has shown outstanding anti-bacterial activity against four tested strains S. aureus, B. Subtilis, K. pneumonia, E. coli. And good antifungal activity against the C. albicans Aspergillus Niger, and C. oxysporum.